W. Nawrocka, M. Zimecki
1997
Citations
0
Influential Citations
22
Citations
Quality indicators
Journal
Archiv der Pharmazie
Abstract
The synthesis of two series of derivatives containing the quinazolinone‐4 moiety is described. 3‐Amino‐2(1H)‐thioxo‐4(3H)‐quinazolinone (1) was subjected to reactions with halogenoketones and halogenoaldehydes, leading to the production of the corresponding ketones, aldehydes, Schiff bases, and 6‐oxo‐1,4,5‐thiadiazin[2,3‐b]quinazoline derivatives. Subsequently, 1 was condensed with selected α,β‐unsaturated carbonyl compounds, aldehydes, ketones, acid chlorides, and esters. The compounds were tested for their potential activity in a model of humoral and cellular immune response. The tests showed that the compounds exhibited differential immunotropic activities. Of particular interest is compound 19, exhibiting a strong stimulatory activity with regard to cellular immune response and compound 16 exerting a strong inhibitory action in both types of the immune response.