R. Schirrmacher, B. Mathiasch, E. Schirrmacher
Sep 1, 2003
Citations
0
Influential Citations
12
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
N-([ 18 F]fluoroalkyl)-N-nitroso-4-methyl-benzensulfonamides [n-alkyl = (-CH 2 ) [ 18,19 F]F, n=2-4)] were synthesized in radiochemical yields ranging from 75-90% to provide new secondary labelling precursors for the syntheses of 18 F-labelled compounds. Preliminary decomposition studies utilizing the corresponding non-radioactive 19 F-compounds as well as the bromo containing analogous compounds were performed to evaluate their stability regarding temperature and basicity of the labelling medium. Furthermore, initial difficulties in labelling these compounds led to the development of a modified labelling procedure applying nearly solvent-free conditions. Extensive decomposition experiments of the new fluoro- as well as the bromo-compounds were conducted under various conditions in order to get experimental data about their stability and reactivity. As a result, different trends for the stability of the bromo as well as the fluoro compounds could be observed.