K. Yamashita, H. Wakamatsu, Y. Sahashi
1954
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Abstract
We modified the phthaloyl method for the syntheses of peptides. In the presence of sodium acetate or potassium acetate, phthalimidoacyl chlorides readily reacted with variousamino acids in glacial acetic acid to give corresponding phthaloyl peptides. By this method we synih-esized following phthaloyl-derivatives; phthaloy l-glycylanilide, -glycylglycine, -glycyl-DL-ala nine, -glycyl-L-leucine, -glycyl-DL-phenylalanine, -glycyl-L-phenylalanine, -glycyl-DL-valine, glycylglycylglycine, -DL-alanyl-DL-alanine, -DL-alanyl-DL-phenylalanine, -DL-phenylalanylglycine, -DL-phenylalanyl-DL-alanine and -DL-phenylalanyl-DL-phenylalanine. By the hydrazinolysis of these phthaloyl peptides we readily obtained corresponding peptides in moderate yield.