H. Otsuka, K. Inouye, F. Shinozaki
Jun 1, 1966
Citations
0
Influential Citations
10
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
t-Butyloxycarbonyl-seryl-(and-glycyl-)tyrosyl-seryl-methionyl-glutamyl-histidyl-phenylalanyl-arginyl-tryptophyl-glycine have been synthesized as the first step of the synthesis of adrenocortico-tropically active peptides. The trifluoroacetic acid treatment of these two compounds afforded the free decapeptides, seryl-tyrosyl-seryl-methionyl-glutamyl-histidyl-phenylalanyl-arginyl-tryptophyl-glycine, which corresponded to the amino-acid sequence of positions 1 to 10 in the corticotropin molecule, and its glycine1-analog. Concerning the synthesis of serine peptides, a tetrapeptide derivative, corresponding to the first four amino acid residues of corticotropin, was obtained by using O-benzyl-serine.