E. Niwa, Hajimu, Tanabe
2007
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Abstract
The establishment of 5-nitro-2-furfural semicarbazone as a drug of the synthetic type has introduced mass-researches finding new derivatives of this type, in which typical ex amples are known as 5-nitro-2-furan-acrylarnide and more recently as 2-(2-furyl)-3-(5-nitro 2-furyl)-acrylamide, and these have been used in medical and other field. However, as well known, these are rather labile as a food preservatives; for example, the heating at 85•Ž for sixty minutes in manufacturing of fish sausage causes break down of one-half of them into ineffective substance to micro-organisms.1) So, it is desirable to prepare a new effective and more stable derivative from chemo therapic as well as other practical standpoint. On the other hand, in the course of synthetic study of furan compounds, found one of the authors that phenylthio-2-furoates showed strong inhibitive action on Trichophyton asteroides.2) Now, the series of derivatives, phenylthio-5-nitro-2-furoates analogous to phenylthio 2-furoates mentioned above and phenyl-5-nitro-2-furoates, were prepared for the study of antibacterial activities. The latters were synthesized with the view to comparative study as to biological ac tivities to the formers.