Y. Nagao, Kweon Kim, S. Sano
Feb 5, 1996
Citations
0
Influential Citations
22
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Various diethyl α-alkynylmalonates (DAM) having potential as cysteine proteinase inhibitors were synthesized by treatment of diethyl acetyliminomalonate (or ketomalonate) with several lithium acetylides. Hydrolytic decarboxylation of the DAM under the mild basic conditions afforded oxazole derivatives or allenyl esters which caused the Michael type reaction with EtSH.