J. Ichikawa, Kotaro Sakoda, H. Moriyama
May 1, 2006
Citations
0
Influential Citations
20
Citations
Journal
Synthesis
Abstract
On treatment of a base such as NaH, KH, or Et 3 N, N-[o-(2,2-difluorovinyl)ben7-yl]- and N-[o-(3,3-difluoroallyl)phenyl]-substituted p-toluenesulfonamides readily undergo intramolecular substitution of sulfonamide nitrogens for vinylic fluorines in a 6-endo-trig fashion, leading to 3-fluoroisoquinoline and 2-fluoro-quinoline derivatives, respectively, in high yields.