P. Yadav, Y. Joshi
Nov 5, 2008
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0
Influential Citations
6
Citations
Journal
Bulletin of The Chemical Society of Ethiopia
Abstract
Reaction of 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (ciprofloxacin) with thiazole/benzothiazole diazonium chloride afforded piperazine substituted ciprofloxacin derivative. The acid part of these derivatives was further condensed with various β-diketones to get 1-cyclopropyl-6-fluoro-4-oxo-7-(4-(thiazol-2-yldiazenyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid derivatives ( 5a-e ) and 7-(4-(benzo[d]thiazol-2-yldiazenyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivatives ( 5f-j ). Structures of these compounds were established on the basis of spectral studies. KEY WORDS: Ciprofloxacin, Thiazole, Benzothiazole, β- Diketone Bull. Chem. Soc. Ethiop. 2008 , 22(3), 459-464.