Shivaraj P. Patil, Shrikant B. Kanawade, Dinesh C. Bhavsar
Mar 1, 2014
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0
Influential Citations
5
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Journal
Journal of Heterocyclic Chemistry
Abstract
New series of (thieno[2,3-c]pyrazolo-5-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 10a, 10b, 10c and (thieno[2,3-c]pyrazol-5-yl)-1,3,4-oxadiazol-3(2H)-yl)ethanones 6a, 6b, 6c has been synthesized from thieno[2,3-c]pyrazole-5-carbohydrazide 3 by multistep reaction sequence. (5-Aryl-1,3,4-oxadiazol-2-yl)-1H-thieno[2,3-c]pyrazoles 4a, 4b, 4c were also synthesized from thieno[2,3-c]pyrazole-5-carbohydrazide 3 by cyclization with various aromatic carboxylic acids. The hydrazide 3 was obtained by reaction of thieno[2,3-c]pyrazole-5-carboxylate 2 with hydrazine hydrate in good yield, and compound 2 was obtained by the reaction of 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde 1 and 2-ethyl thioglycolate in presence of sodium alcoholate in good yield.