Wang Dun
2003
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Influential Citations
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Quality indicators
Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To design and prepare some new derivatives of 6-bromo-5-hydroxyindole-3-carboxylic acid ethyl ester and to determine their antiviral activity in vitro . Method The target compounds were synthesized in several steps with the starting materials quinone and 3-ethylaminocrotonate,their antiviral activities in vitro against human influenza A3 and respiratory syncytial virus(RSV)were examined respectively in the MDCK cell culture and HeLa cell culture with virus cytopathic effect assay.Results and Conclusion The twelve derivatives of 6-bromo-5-hydroxyindole-3-carboxylic acid ethyl ester were synthesized whose structures were confirmed by 1H-NMR and MS.The pharmacological results show compoud Ⅵ_j has the same potent antiviral activity as the control drug amantadine.