M. S. Reddy, Yalla Kiran Kumar, N. Thirupathi
Jan 25, 2012
Citations
0
Influential Citations
50
Citations
Journal
Organic letters
Abstract
An efficient conversion of 4-bromo-3-yn-1-ols to γ-butyrolactones via AuCl(3)-catalyzed electrophilic cyclization (hydroxyl-assisted regioselective hydration) in wet toluene is described. Various secondary and tertiary alcohols including benzylic systems were found to be equally reactive with moderate to excellent yields obtained in all cases.