M. Iqbal, Ying-fa Li, P. Evans
Mar 8, 2004
Citations
0
Influential Citations
34
Citations
Journal
Tetrahedron
Abstract
Abstract The synthesis of racemic Δ12,14-15-deoxy-PG-J1 is readily achieved in six steps employing as the key transformation a one-pot conjugate addition–Peterson olefination sequence using exo-2-trimethylsilyl-3a,4,7,7a-tetrahydro-4,7-methanoinden-1-one. Additionally a Noyori-type three-component coupling approach is employed for the synthesis of enantioenriched epi-Δ12-15-deoxy-PG-J1 from 4(S)-tert-butyldimethylsilyloxycyclopent-2-enone.