A. Leusen, Fokko J. Schaart, D. V. Leusen
Sep 2, 2010
Citations
0
Influential Citations
13
Citations
Journal
Recueil des Travaux Chimiques des Pays-Bas
Abstract
1-Isocyano-1-tosyl-1-alkenes (1) are useful new synthons. They are obtained by dehydration of the corresponding N-(1-tosyl-1-alkenyl)formamides (4), which are reaction products of tosylmethyl isocyanide (2) and aldehydes or ketones. 1-Isocyano-1-tosyl-1-alkenes 1 react smoothly with primary aliphatic amines (or ammonia) to give 1,5-disubstituted (or 5-monosubstituted) imidazoles (7) in high yields.