G. Slegers, J. Sambre, P. Goethals
1986
Citations
0
Influential Citations
14
Citations
Journal
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes
Abstract
Abstract A method for the synthesis of [ 11 C]iodoethane, a useful precursor for labelling of molecules of biomedical interest, has been developed. 11 CO 2 prepared by irradiation of nitrogen gas with 18 MeV protons, is converted into [ 11 C]ethanol by a Grignard reaction with methylmagnesium bromide, followed by reduction with lithium aluminum hydride and hydrolysis with hydrochloric acid. [ 11 C]Iodoethane is produced by reaction of [ 11 C]ethanol with hydriodic acid. The purification is performed by gaschromatography on Porapak Q. For a 20 min irradiation at, 15 μA intensity the method yields about 370 mCi† of radiochemically pure [ 11 C]iodoethane with a specific activity of 180–300 mCi/μmol at the end of synthesis, 23 min after irradiation.