Xukai Guan, Heng-Xia Zhang, Jigang Gao
Sep 20, 2019
Citations
0
Influential Citations
17
Citations
Journal
The Journal of organic chemistry
Abstract
Chiral imidodiphosphoric acids were employed as efficient catalysts in the enantioselective addition reaction of pyrrole and indoles to 3-vinylindoles. A series of optically active 1,1,1-triarylethmanes bearing quaternary stereocenters were synthesized in excellent yields (up to 99% yield) and enantioselectivities (up to 98% ee). Gram-scale reaction of 1i and 2a as well as 1o and 5a demonstrated the synthetic utility of this methodology. Control experiment showed that the formation of double H-bond between catalyst and substrates is necessary for the excellent outcome.