C. Prenant, J. Sastre, C. Crouzel
Feb 1, 1987
Citations
0
Influential Citations
36
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
A method is described by which 100 mCi of pindolol may be obtained from about 1.5 Ci 11CO2 in 30 minutes. The product is chromatographically pure, sterile and apyrogenic with a specific activity between 600 and 1000 mCi/μmole at the time of use. The synthesis involves the preparation of 11C-acetone followed by fixation of the isopropyl group on the precursor : 2 hydroxy-3 (4-indolyoxy) propylamine by formation of an imine, the reduction of the latter by sodium cyanoborohydride.