Chen Wen
2006
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Journal
Chinese Journal of Pharmaceuticals
Abstract
11H-Dibenzo[b,f]thiepin-10-one,a key intermediate of anti-inflammatory zaltoprofen,was synthesized from 2-chlorobenzaldehyde by Ullmann condensation,reduction with NaBH_4,chloration with conc.HCl,cyanidation, hydrolysis and cyclization with an overall yield of 48%.