David Monge, Kim L. Jensen, I. Marín
Jan 21, 2011
Citations
0
Influential Citations
65
Citations
Journal
Organic letters
Abstract
A convenient, efficient synthesis of 1,2,4-triazolines from α-isocyano esters/amides and azodicarboxylates is presented. The developed reaction cascade is based on a base-catalyzed hydrazination-type reaction followed by a subsequent cyclization providing the triazolines in good to excellent yields (75-99%). Phosphine-catalyzed and preliminary asymmetric phase-transfer catalysis approaches have also been investigated.