A. Astakhov, R. Zubatyuk, R. Abagyan
Jan 9, 2014
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Influential Citations
7
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Journal
Chemistry of Heterocyclic Compounds
Abstract
The condensation of 3-alkylamino-5-amino-1-phenyl[1,2,4]triazoles with β-keto esters or diethyl ethoxymethylenemalonate in the presence of acetic acid proceeds selectively to give 3-alkylamino-1-phenyl[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones. The observed reaction pathway is explained using quantum-chemical calculations of the energies of possible isomeric heterocyclization products.