A. Kudelko, Karolina Jasiak
May 8, 2013
Citations
0
Influential Citations
6
Citations
Journal
Synthesis
Abstract
A novel and efficient synthesis of 5-substituted 2-[2-(2-furyl)ethenyl]-1,3,4-oxadiazoles and 2-[2-(2-thienyl)ethenyl]-1,3,4-oxadiazoles by cyclocondensation of the appropriate 3-(2-furyl)- and 3-(2-thienyl)acrylohydrazides with triethyl orthoesters in the presence of glacial acetic acid is reported. The formation of symmetrically substituted 2,5-bis[2-(2-furyl)ethenyl]-1,3,4-oxadiazole and 2,5-bis[2-(2-thienyl)ethenyl]-1,3,4-oxadiazole from the corresponding N , N ′-diacylhydrazines under the influence of phosphorus oxychloride is also described.