C. Lavey, D. Hesk, David Koharski
Apr 1, 2011
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The preparation of [3H]Sch 727965 from unlabeled compound and tritiated water was base catalyzed. Diethyl [13C3]malonate was used to prepare [13C3]Sch 727965 in five steps in 21.8% overall yield. In a similar manner, [14C]Sch 727965 was prepared in five steps from diethyl [2-14C]malonate in 11.1% radiochemical yield. Copyright © 2010 John Wiley & Sons, Ltd.