J. Ares, K. Wehmeyer
Jul 1, 1994
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The 13C6-labelled molecules, flavone and 5-methoxyflavone, with the carbon-13 label at all six carbons of the aromatic B ring, have been prepared for use as internal standards in isotope dilution-mass spectrometry. The key step involves addition of a labelled benzoyl group to the methyl group of a hydroxyacetophenone, forming a 1,3-diketone. Overall yields from 13C6-benzoic acid were 38% for the labelled flavone and 45% for the labelled 5-methoxyflavone.