V. Burmistrov, E. Rasskazova, V. D'yachenko
Oct 7, 2019
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Journal
Russian Journal of Organic Chemistry
Abstract
To assess the effect of the lipophilicity of different parts of urea molecules on their activity as soluble epoxide hydrolase inhibitors, a series of 1,3-disubstituted ureas containing cycloheptane and bicyclo-[2.2.1]heptane fragments were prepared by the reaction of isocyanates with corresponding amines in 78–94% yields.