Qiao Lin-lin
2009
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Journal
Fine Chemical Intermediates
Abstract
1-[3-(Trifluoromethy1)pheny1]-2-propanone was synthesized from 1-bromo-3-(trifluoromethyl)benzene via Grignard reaction and oxidation with a mixture of Na2Cr2O7 and concentrated sulfuric acid as the oxidant.The results showed that an overal yield of 82.5% was obtained under the following conditions:n(Na2Cr2O7):n(H2SO4)=1:4.CuBr as the catalyst,reaction time 3h at 5℃.The product was characterized by IR and 1H NMR.