Jiang Peng-fei
2011
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Journal
Journal of Hebei Normal University
Abstract
1,4-bis(chloroacetyl)piperazine was prepared from anhydrous piperazine and chloroacetyl chloride using water as solvent in the presence of anhydrous sodium carbonate.Technological parameters involved in this reaction were optimized.Under the optimized conditions:the molar ratio of anhydrous piperazine and chloroacetyl chloride was 1∶2.2,reaction temperature-6 ℃,reaction time 60 min,the yield counting with anhydrous piperazine was 83.9 %.The product structure was conformed to target product through1HNMR and MS analysis and determination.