Wu Qiuye
2005
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Journal
Practical Journal of Medicine&Pharmacy
Abstract
Objective To study improved synthetic method of 1-[(4-chlorophenyl)phenylmethyl]-piperazine, the intermediate of cetirizine hydrochloride.Methods Chlorobenzene and benzoyl chloride were used as starting reagents,and the title compounds were synthesized then by reduction etc.3 steps reaction.Results and Conclusion A novel synthetic method was completed.This method is economical and practical, higher yield(th recovery rate,53%), and were able to be used in industrializations.