M. Kurosawa, Katsunori Tanaka, K. Fukase
Dec 15, 2010
Citations
0
Influential Citations
0
Citations
Journal
Radioisotopes
Abstract
L-Propargylglycine was efficiently labeled with 14C at the 1- and 2- positions. The synthesis was achieved according to the scheme illustrated in Fig.1. Ni-complex of Schiff's base, Gly-Ni-BPB(4) was derived from [U-14C]glycine(2) and (S)-BPB(3). Diastereoselective alkylation of 4 with propargyl bromide followed by acid hydrolysis afforded L-propargyl[1, 2-14C]glycine(1). The optical purity of 1was proved to be 97.0% and the overall yield of 1 from 2 was 28.2%.