A. Crowe, C. Johnston, K. Lawrie
May 1, 1992
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0
Influential Citations
4
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Pantoprazole 1, SK & F 96022Z, an H+/K+ ATPase inhibitor has been prepared, radiolabelled with carbon-14, in two positions, for drug metabolism studies. [Benzimidazole-2-14C]Pantoprazole in 4 steps from potassium ethyl [14C]xanthate, and [pyridylmethyl-14C]pantoprazole from cuprous [14C]cyanide in 8 steps. The overall radiochemical yields of these syntheses were 37.9% and 5.2% respectively.