K. T. Garnes, J. Heys, S. Landvatter
Dec 5, 1989
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0
Influential Citations
2
Citations
Journal
Journal of Organometallic Chemistry
Abstract
Abstract Bis[1,2-bis(diphenylphosphino)ethane]gold(I) 2-hydroxypropanoate (SK & F 104524) has been synthesized in carbon-14 ( 2b ) and gold-195 ( 2c ) labeled forms. The radiolabeled products were formed via reaction of labeled [μ-1,2-bis(diphenylphosphino)ethanebis(gold(I) chloride)] with excess 14 C-labeled or unlabeled bis(diphenylphosphino)ethane (dppe). Carbon-14 labeled [μ-1,2-bis(diphenylphosphino)-ethane]bis[(1-thio-β- d -glucopyranosato- S )gold(I)] ( 1 , SK&F 102912) was prepared via the same intermediate. The key intermediate in these syntheses, [μ-1,2-bis(diphenylphosphino)ethanebis(gold(I) chloride)] ( 4a,4b ), was prepared in carbon-14 labeled form using [ 14 C]dppe, and in gold-195 labeled form from chloro[ 195 Au]auric acid. [ 14 C 2 ]Dppe was prepared in good yield by the double addition of diphenyl phosphide anion to the inexpensive and readily available [ 14 C 2 ]acetylene. Hence, these syntheses provide means of obtaining radiolabeled phosphine complexes that are commercially unavailable.