Zhuang Yuan-yuan, Guo Shuang-xi, D. Ting
2014
Citations
0
Influential Citations
0
Citations
Journal
Fine chemicals
Abstract
6-Bromo-2-naphthol( Ⅳ) was prepared from 2-naphthol( Ⅱ) via a two-step one-pot process in a yield of 89. 0%; then,6-cyano-2-naphthol( Ⅴ) was synthesized from Ⅳ under the feeding ratio of n( CuCN) ∶n( Ⅳ) = 1. 5 ∶1 in a yield of 91. 2%. In the end,the bromination reagents Br 2 and NBS were both adopted to prepare 1-bromo-6-cyano-2-naphthol( Ⅰ) from Ⅴ. In the case of Br 2 as bromination reagent,acetic acid as solvent,n( Br 2) ∶n( Ⅴ) =1∶1,the yield was 89. 8%; this process is low-cost and suitable for industrialization. In the case of NBS as bromination reagent,acetonitrile as solvent,n( NBS) ∶ n( Ⅴ) = 1. 00 ∶1. 03,the yield is 99. 2%; this method is mild,simple,efficient for laboratory-scale preparation,in which the problems of volatilization and high inhalation toxicity of Br 2 can be avoided.