N. Pokhodylo, R. Savka, M. Obushak
Aug 1, 2020
Citations
0
Influential Citations
4
Citations
Journal
Russian Journal of Organic Chemistry
Abstract
A convenient synthetic approach to (1H-1,2,3-triazol-1-yl)acetic acid derivatives via the reaction of azidoacetamides with β-ketoesters and acetylacetone is proposed. Based on this strategy, 1,5-disubstituted 1,2,3-triazoles were prepared from available reagents under metal-free conditions. A one-pot protocol for the synthesis of (5-methyl-1H-1,2,3-triazol-1-yl)acetamides derived from N-substituted chloroacetamides is developed.