G. M. Manahelohe, K. Shikhaliev, Andrey Potapov
Jul 31, 2015
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Journal
European Chemical Bulletin
Abstract
This study is concerned with the synthesis and characterization of derivatives of 1H-1,2-dithiol-1-thiones and thioamides having the hydroquinoline moiety. 5-Alkyl-8-(carbonothioyl)-4,5-dihydro-4,4-dimethyl-1H-[1,2]dithiolo[3,4- c ]quinoline-1-thiones are synthesized via the reaction of N-alkyl-2,2,4-trimethyl-1,2-dihydroquinoline-6-carbaldehydes, cyclic secondary amines and excess elemental sulfur (7.33 equivalents) in refluxing N, N-dimethylformamide. A series of thioamides derivatives containing hydroquinoline fragment are obtained in 56-84% yields by the three-component reaction of N-alkylhydroquinoline-6-carbaldehydes, cyclic secondary amines and 1.33 equivalent of elemental sulfur under refluxing temperature in N, N-dimethylforamide.