A. Bijev, P. Prodanova, A. Nankov
2003
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Journal
Bulgarian Chemical Communications
Abstract
Fourteen new substituted 1H-1-pyrrolylcarboxamides of pharmacological interest have been synthesised via acyl chlorides. The pyrrole compounds used as N-acylating agents were as follows: 2-[3-(ethoxycarbonyl)-2,5-dimethyl-1H-1-pyrrolyl]acetic acid, 2-[3-(ethoxycarbonyl)-2-methyl-5-phenyl-1H-1-pyrrolyl]acetic acid, 2-[3-(ethoxycarbonyl)-2,4-dimethyl-5-phenyl-1H-1-pyrrolyl]acetic acid and 2-[3-(acetyl)-2,4-dimethyl-5-phenyl-1H-1-pyrrolyl]acetic acid. The relevant reaction partners were 6 amines: N,N-diethylamine, pyrrolidine, morpholine, piperidine, 1-benzhydrylpiperazine, 4-phenyl-1,3-thiazol-2-amine. The latter needed preliminary activation by N-silylation because of its lower nucleophilicity. The newly synthesised 1H-1-pyrrolylcarboxamides have been characterised and identified by TLC, NMR and IR spectroscopy.