Ar Park, Kyu‐Sung Jeong, Hyuk-Won Lee
Feb 23, 2021
Citations
0
Influential Citations
5
Citations
Journal
ACS Omega
Abstract
We described a silver(I)-mediated intramolecular oxidative C–H amination that enables the construction of assorted 1H-indazoles that are widely applicable in medicinal chemistry. The developed amination was found to be efficient for the synthesis of a variety of 3-substituted indazoles that are otherwise difficult to be synthesized by other means of C–H aminations. Preliminary mechanistic studies suggested that the current amination proceeds via single electron transfer (SET) mediated by Ag(I) oxidant.