B. Medaer, K. V. Aken, G. Hoornaert
Jun 24, 1996
Citations
0
Influential Citations
11
Citations
Journal
Tetrahedron
Abstract
Abstract 3,5-dichloro-2 H -1,4-oxazin-2-ones and 3-chloro-2 H -1,4-benzoxazin-2-ones are reacted with bifunctional reagents as sodium azide and diazocompounds to yield bi(tri)cyclic tetrazolo- or triazolo fused intermediates via an intramolecular cyclisation reaction. Conversion of these lactone inter-mediates with various nucleophiles generates new substituted 1 H -tetrazoles or 1,2,3-triazoles useful for pharmacological screening and for further elaboration via the α-chloroketone substituent at N-1.