Shao Ying-lu
2007
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0
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Journal
Journal of Shenyang Pharmaceutical University
Abstract
Objective To prepare 1-methyl1,2,3,4-tetrahydroisoquinoline and simplify the synthetic method.Methods 1-Methyl-1,2,3,4-tetrahydroisoquinoline was synthesized from phenethylamine through three steps:acetylation with acetyl chloride,cyclization with PPA and reduction with potassium borohydride.Results The structure of 1-methyl -1,2,3,4-tetrahydroisoquinoline was identified by 1H-NMR spectroscopy.Conclusions The method of preparation is much easier to perform and work up with cheaper starting material and fewer by-products.