Charles Q. Huang, K. Wilcoxen, J. Mccarthy
Oct 16, 2003
Citations
0
Influential Citations
4
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
1-Methyl-3-phenylpyrazolo[4,3-b]pyridines were synthesized via a cyclization reaction of 1-methyl-4-amino-3-phenylpyrazoles 8 with ethyl acetoacetate. Optimization of this series of compounds resulted in CRF(1) antagonists with subnanomolar binding affinity. Compounds bearing a polar group such as methoxy or hydroxy were also found to be very active.