Wang Dong-hua
2007
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Fine chemicals
Abstract
1-Methyl-4-piperidone was obtained from a methanol solution of methylamine and methyl acrylate through Michael addition,Dieckmann cyclization and decarboxylation.Thus,with n(methyl acrylate)/n(methylamine)=2.2 and n(sodium methoxide)/nmethyl-di-(β-methoxycarbonylethyl)amine=1.14,Michael addition at 25 ℃,Dieckmann cyclization at 80~83 ℃ and decarboxylation at 100~103 ℃,the total yield of 1-methyl-4-piperidone was 58%.500 L reactor pilot test was successfully carried out.