D. Tytgat, M. Gelbcke, D. Smith
Nov 1, 1990
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0
Influential Citations
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Journal
Die Pharmazie
Abstract
A novel synthesis of (1R,2S)- and (1S,2S)-1-phenyl-1,2-propanediamines by highly regioselective and stereo-specific opening of chiral aziridines is reported. This method permits the synthesis of optically pure diastereomers. A hypothermic effect is observed after intracerebroventricular injection in rats.