K. Akhter, K. Jahan, M. E. Halim
Mar 25, 2019
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0
Influential Citations
3
Citations
Journal
Bangladesh Journal of Scientific and Industrial Research
Abstract
We report herein the use of nickel nitrate hexahydrate [Ni(NO3)2.6H2O] as a new catalyst for the one-pot Biginelli like reaction coupling of 1-phenyl thiourea, ethyl acetoacetate and aromatic aldehydes to afford the corresponding 1-phenyl-3,4-dihydropyrimidin-2(1H)-thiones under solvent free condition to avoid the usage of hazardous organic solvents. The synthesized compounds were evaluated for their antimicrobial activity by KIRBY-BAUER disk diffusion method. Most of the compounds showed good to moderate antimicrobial activity. Bangladesh J. Sci. Ind. Res.54(1), 47-54, 2019