C. Beinat, S. Banister, C. McErlean
Sep 25, 2013
Citations
1
Influential Citations
7
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The rigid piperazine homologue 2,5-diazabicyclo[2.2.1]heptane (DBH) finds extensive application in medicinal chemistry and pharmaceutical research, but access to this scaffold is non-trivial. This letter details a concise synthetic sequence that gives ready access to DBH on gram scale. The route features a Staudinger reduction of an azide to facilitate a transannular cyclisation