R. G. Glushkov, N. Marchenko, I. Levshin
May 1, 1997
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0
Influential Citations
2
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Journal
Pharmaceutical Chemistry Journal
Abstract
Within the framework of this investigation, we have obtained several derivatives of 6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid having, besides the aryl fragments, some other substituents in position 1 that account for the high antibacterial activity in the series of fluoroquinolones [4]. Ethyl esters of 3-ethoxy and 3-dimethylamino-2-(5-nitro2,4-dichlorobenzoyl)acrylie acids (IVa, IVb) [1, 5, 6] were used as the base substance. Both compounds react under mild conditions with various anilines to form secondary enamines V. It should be noted that the reaction can be performed with the amine bases as well as with their hydrochlorides. Enami-