Walid Fathalla, S. E. Rayes, I. Ali
Dec 12, 2007
Citations
0
Influential Citations
15
Citations
Journal
Arkivoc
Abstract
A new and convenient synthesis of a variety of methyl-2-(2-(4,5-dihydro-4-methyl-5-oxo[1,2,4]triazolo[4,3-a]quinazolin-1-yl-thio) acetamido and propanamido alkanoate 8a-h and 9a-c, respectively has been developed via azide and DCC coupling methods. Hydrazinolysis of the ester 8a-g gave the hydrazide 10a-g, which subsequently reacted with furfural to give the hydrazone 11a-f. Compounds 8-11 might show non sedative H1-antihistamines activities. Compounds 8-11 were characterized by elemental analysis, IR, mass and H NMR data.