P. Pointeau, Y. Berger
Nov 1, 1994
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Sodium [1-14C] isobutyrate: 1 was obtained by carbonation of isopropyl magnesium bromide with 14CO2. From: 1 [1-14C] isobutyryl chloride: 3 was prepared, which through the successive actions of diazomethane and hydrogen bromide gave rise to 1-bromo 3 methyl [2-14C] 2-butanone: 5. The latter lead to the indolizine: 6 which by a route patterned after that used to make unlabelled Fantofarone gave the [2-14C-indolizyl] Fantofarone: 8 (specific radioactivity: 58.2 mCi/mMole) overall yield 9.9% based on [14C] BaCO3.