B. Manz, M. Govindan
1980
Citations
0
Influential Citations
3
Citations
Journal
Hoppe-Seyler's Zeitschrift fur physiologische Chemie
Abstract
The preparation of 21-diazo-9 alpha-fluoro-16 alpha-methyl-21-deoxy-[1,2(n)-3H]prednisolone is described. [1,2(n)-3H]Dexamethasone 26 Ci/mmol, was oxidized with cupric acetate/air to give the 21-aldehyde. Treatment of the aldehyde with hydroxylamine gave the corresponding 21-oxime which was reacted with chloroamine to give a 25--35% yield of 21-diazo-9 alpha-fluoro-16 alpha-methyl-21-[1,2(n)-3H]deoxyprednisolone with a specific activity of 25--26 Ci/mmol.