Y. Ri-sheng
2010
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Journal
Chinese Journal of Pharmaceuticals
Abstract
2-(1-Imidazolyl)ethanamine was synthesized from ethyl acrylate by Michael addition with imidazole to give ethyl 3-(1-imidazolyl)propionate,which was subjected to hydrazinolysis,followed by the Curtius rearrangement and hydrolysis with an overall yield of about 72%.