Li Ming-zhu
2007
Citations
0
Influential Citations
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Citations
Quality indicators
Journal
Journal of Medical Science Yanbian University
Abstract
OBJECTIVE To synthesize the ethyl 2-[1-(pyridin-2-yl)ethoxy] acetate and 3~6 of derivant as well as its effects for ability of memory in mice.METHODS The compounds were prepared using 2-ethylpyridine,through Whol-Ziegler reaction,and Williamson reaction and esterification.Memory facilitation in mice was studied by swimming maze test.RESULTS The mistake frequency and arrival time in mice with large and small dose of 2-dimethylamino ethyl 2-[1-(pyridin-2-yl)ethoxy]acetate hydrochloride were significantly decrease as compared with alcohol group,and there were significant differents between two groups.CONCLUSION 2-dimethylamino ethyl 2-[1-(pyridin-2-yl)ethoxy]acetate hydrochloride has memory facilitation in mice.