Yin Shu-mei
2006
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Journal
Journal of Qingdao University of Science and Technology
Abstract
2-(2-Amino-4-thiazolyl)-2-[[(Z)-(t-butoxycarbonyl)methoxy]imino]acetic acid 2-benzothiazolyl thioester was synthesized by condensing(Z)-2-amino-[[2-(t-butoxy)-2-oxoethoxy]imino]-4-thiazoleacetic acid(ADTAC) with 2,2-dithio-bis-benzothiazole(DM).The optimum conditions for the condensation were: n(ADTAC):n(DM):(n(N-)methylmorpholine): n(triethyl phosphite)=1.0∶2.0∶1.4∶2.4,reaction temperature 0~15℃,adding time of triethyl phosphite 2~4 h,and reaction time 1 h. Under above conditions,the yield and weight percent of the title compound were 70% and 100%(based on standard sample) respectively,melting point of it was 140~142 ℃.