Chen An-cheng
2012
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Journal
Fine Chemical Intermediates
Abstract
2-(2-Aminothiazol-4-yl)-(Z)-2-(methoryimion)acetate was synthesized from ethyl acetoacetate by oximation,methylation,halogenation and cyclic reaction in overall yield of 46%.The products from oximation and methylation were not necessary of separation and purification,therefore the process was simplified.Replacement of bromine with sulfuryl chloride as the halogenating reagent reduced the costs of the reaction.The influences of different factors on chlorination were investigated.The structure of the title compound was determined with FT-IR,1H NMR and LC-MS.