Yan Zong-gang
2010
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Zhejiang Chemical Industry
Abstract
The basic characteristics of one related intermediate 2,2-difluoroethanol and several synthetic methods in accordance with different raw materials were introduced. These methods include the reduction of difluoroacetic acid or acetate by metal borohydride, the catalytic hydrogenation of difluoroacetyl chloride, the esterification and hydrolysis of 1,1-difluoro-2-bromo(or chloro) ethane. Among them, catalytic hydrogenation of difluoroacetyl chloride has some advantages over others: the commercial available reagents, the simple reaction conditions and equipments, and the satisfactory yield. Therefore, difluoroacetyl chloride as starting material is most suitable for industrialized production.